The skin serves as the primary interface between our body and the external environment
and acts as a barrier against entry of physical agents, chemicals, and microbes …

Psoriasis is a complex chronic inflammatory skin disease caused by the dynamic interplay
between multiple genetic risk foci, environmental risk factors, and excessive immunological …

Abstract Development of immunocompetent T cells in the thymus is required for effective
defence against all types of pathogens, including viruses, bacteria and fungi. To this end, T …

The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and
IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric …

The skin barrier would not function without IL-1 family members, but their physiological role
in the immunological aspects of skin barrier function are often overlooked. This review …

Abstract The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the
functioning of innate and adaptive immunity and the genesis of inflammation. They are …

TNF and IL-17 are two cytokines that drive dysregulated keratinocyte activity, and their
targeting is highly efficacious in patients with psoriasis, but whether these molecules act with …

Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder
characterized by recurrent flares associated with skin erythema, desquamation, and …

Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and
adaptive immunity. They play important roles in host defense, but excessive immune …

Generalized pustular psoriasis (GPP) is a severe, relapsing, immune-mediated disease
characterized by the presence of multiple sterile pustules all over the body. The exact …