The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …

A growing number of variants associated with risk for neurodevelopmental disorders have
been identified by genome-wide association and whole genome sequencing studies. As …

Background The transcription factor CTCF appears indispensable in defining topologically
associated domain boundaries and maintaining chromatin loop structures within these …

Blinatumomab is an efficacious immunotherapeutic agent in B cell acute lymphoblastic
leukemia (B-ALL). However, the pharmacogenomic basis of leukemia response to …

Hyperconserved genomic sequences have great promise for understanding core biological
processes. It has been recently proposed that scores of hyperconserved 5′ untranslated …

Background: Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged
as a promising strategy to remuscularize injured myocardium. However, it is insufficient to …

Background CTCF is a well-established chromatin architectural protein that also plays
various roles in transcriptional regulation. While CTCF biology has been extensively studied …

Dysregulation of the oncogenic transcription factor HOXA9 is a prominent feature for most
aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in …

Accumulating evidence indicates that HOXA9 dysregulation is necessary and sufficient for
leukemic transformation and maintenance. However, it remains largely unknown how …

Unfolded protein response (UPR) maintains the endoplasmic reticulum (ER) homeostasis,
survival, and physiological function of mammalian cells. However, how cells adapt to ER …