Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

The past 20 years have seen many advances in our understanding of protein-protein
interactions (PPIs) and how to target them with small-molecule therapeutics. In 2004, we …

Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

Cysteine (Cys), as an important biothiol, plays a major role in many physiological processes
like protein synthesis, detoxification and metabolism, and also is closely associated with a …

Molecules that stabilize protein–protein interactions (PPIs) are invaluable as tool
compounds for biophysics and (structural) biology, and as starting points for molecular glue …

An unambiguous description of an experiment, and the subsequent biological observation,
is vital for accurate data interpretation. Minimum information guidelines define the …

19F NMR has emerged as a powerful tool in drug discovery, particularly in fragment-based
screens. The favorable magnetic resonance properties of the fluorine-19 nucleus, the …

Cysteine (Cys) and homocysteine (Hcy) are essential for maintaining the cellular redox
homeostasis and play critical roles in pathological and physiological processes. The …

Protein-protein interactions (PPI) are involved in virtually every cellular process and thus
represent an attractive target for therapeutic interventions. A significant number of protein …

The kinase-inducible domain interacting (KIX) domain is a highly conserved independently
folding three-helix bundle that serves as a docking site for transcription factors, whereupon …