Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …

Tocilizumab (TCZ), is a recombinant humanized anti-interleukin-6 receptor (IL-6R)
monoclonal antibody which has a main use in the treatment of rheumatoid arthritis, systemic …

The human immune system involves highly complex and coordinated processes in which
small proteins named cytokines play a key role. Cytokines have been implicated in the …

Background Immunogenicity of aTNFs is one of the mechanisms behind treatment failure.
Objective To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab …

Background Drug survival (time to drug discontinuation) has recently emerged as an
important parameter reflecting the long‐term therapeutic performance in a real‐life setting …

The availability of monoclonal antibodies has revolutionized the treatment of an increasingly
broad spectrum of diseases. Inflammatory diseases are among those most widely treated …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by polyarthritis.
Numerous agents with varying mechanisms are used in the treatment of RA, including non …

Importance One-third of patients with rheumatoid arthritis show inadequate response to
tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Objective To evaluate drug survival, effectiveness, pharmacokinetics, immunogenicity, and
safety in daily practice after transitioning treatment from original reference infliximab …