An integrative view of cisplatin-induced renal and cardiac toxicities: Molecular mechanisms, current treatment challenges and potential protective measures
GJ Dugbartey, LJ Peppone, IAM de Graaf - Toxicology, 2016 - Elsevier
Cisplatin is currently one of the most widely-used chemotherapeutic agents against various
malignancies. Its clinical application is limited, however, by inherent renal and cardiac …
malignancies. Its clinical application is limited, however, by inherent renal and cardiac …
Glutathione efflux and cell death
R Franco, JA Cidlowski - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Glutathione (GSH) depletion is a central signaling event that regulates the
activation of cell death pathways. GSH depletion is often taken as a marker of oxidative …
activation of cell death pathways. GSH depletion is often taken as a marker of oxidative …
Natural compounds and glutathione: Beyond mere antioxidants
The tripeptide glutathione plays important roles in many cell processes, including
differentiation, proliferation, and apoptosis; in fact, disorders in glutathione homeostasis are …
differentiation, proliferation, and apoptosis; in fact, disorders in glutathione homeostasis are …
Recent updates on viral Oncogenesis: Available preventive and therapeutic entities
Human viral oncogenesis is a complex phenomenon and a major contributor to the global
cancer burden. Several recent findings revealed cellular and molecular pathways that …
cancer burden. Several recent findings revealed cellular and molecular pathways that …
Repurposing of antimicrobial agents for cancer therapy: what do we know?
C Pfab, L Schnobrich, S Eldnasoury, A Gessner… - Cancers, 2021 - mdpi.com
Simple Summary Despite the leaps and bounds in the prevention and treatment of cancer, it
remains the second leading cause of death worldwide. A significant hurdle during cancer …
remains the second leading cause of death worldwide. A significant hurdle during cancer …
Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism
Purpose: Cancer cells (relative to normal cells) show increased steady-state levels of
hydroperoxides that are compensated by increased glucose and hydroperoxide metabolism …
hydroperoxides that are compensated by increased glucose and hydroperoxide metabolism …
Drug rechanneling: A novel paradigm for cancer treatment
Cancer continues to be one of the leading contributors towards global disease burden.
According to NIH, cancer incidence rate per year will increase to 23.6 million by 2030. Even …
According to NIH, cancer incidence rate per year will increase to 23.6 million by 2030. Even …
New palladium (II) complexes bearing pyrazole-based Schiff base ligands: Synthesis, characterization and cytotoxicity
Reactions of 5-hydrazino-1, 3-dimethyl-4-nitro-1H-pyrazole (1) with substituted
benzaldehydes (2–5) in methanol gave the new substituted benzaldehyde (1, 3-dimethyl-4 …
benzaldehydes (2–5) in methanol gave the new substituted benzaldehyde (1, 3-dimethyl-4 …
Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood–brain barrier endothelial …
The era of highly active antiretroviral therapy (HAART) has controlled AIDS and its related
disorders considerably; however, the prevalence of HIV-1-associated neurocognitive …
disorders considerably; however, the prevalence of HIV-1-associated neurocognitive …
Acquisition of cisplatin resistance shifts head and neck squamous cell carcinoma metabolism toward neutralization of oxidative stress
Background: Cisplatin (CDDP) is commonly utilized in the treatment of advanced solid
tumors including head and neck squamous cell carcinoma (HNSCC). Cisplatin response …
tumors including head and neck squamous cell carcinoma (HNSCC). Cisplatin response …