Innovative treatment strategies to accelerate wound healing: trajectory and recent advancements

P Kolimi, S Narala, D Nyavanandi, AAA Youssef… - Cells, 2022 - mdpi.com
Wound healing is highly specialized dynamic multiple phase process for the repair of
damaged/injured tissues through an intricate mechanism. Any failure in the normal wound …

Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

A Nourian Dehkordi, F Mirahmadi Babaheydari… - Stem cell research & …, 2019 - Springer
Normal wound healing is a dynamic and complex multiple phase process involving
coordinated interactions between growth factors, cytokines, chemokines, and various cells …

Review of the current trends in clinical trials involving induced pluripotent stem cells

JY Kim, Y Nam, YA Rim, JH Ju - Stem cell reviews and reports, 2022 - Springer
In 2006, the induced pluripotent stem cell (iPSC) was presented to the world, paving the way
for the development of a magnitude of novel therapeutic alternatives, addressing a diverse …

Studying human nociceptors: from fundamentals to clinic

SJ Middleton, AM Barry, M Comini, Y Li, PR Ray… - Brain, 2021 - academic.oup.com
Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

The development and function of lung-resident macrophages and dendritic cells

M Kopf, C Schneider, SP Nobs - Nature immunology, 2015 - nature.com
Gas exchange is the vital function of the lungs. It occurs in the alveoli, where oxygen and
carbon dioxide diffuse across the alveolar epithelium and the capillary endothelium …

Engineering bioactive scaffolds for skin regeneration

M Hosseini, A Shafiee - Small, 2021 - Wiley Online Library
Large skin wounds pose a major clinical challenge. Scarcity of donor site and postsurgical
scarring contribute to the incomplete or partial loss of function and aesthetic concerns in skin …

Beyond stem cells: self-renewal of differentiated macrophages

MH Sieweke, JE Allen - Science, 2013 - science.org
Background Many mature cells of the body are continuously replaced, particularly in tissues
that are most exposed to the environment such as cells of the immune system. The need for …

Mammalian Krüppel-like factors in health and diseases

BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

[HTML][HTML] Induction of pluripotent stem cells from adult human fibroblasts by defined factors

K Takahashi, K Tanabe, M Ohnuki, M Narita, T Ichisaka… - cell, 2007 - cell.com
Successful reprogramming of differentiated human somatic cells into a pluripotent state
would allow creation of patient-and disease-specific stem cells. We previously reported …

Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

AE Omole, AOJ Fakoya - PeerJ, 2018 - peerj.com
The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was
heralded as a major breakthrough of the decade in stem cell research. The ability to …