Effects of glucose metabolism, lipid metabolism, and glutamine metabolism on tumor microenvironment and clinical implications

L Zhu, X Zhu, Y Wu - Biomolecules, 2022 - mdpi.com
In recent years, an increasingly more in depth understanding of tumor metabolism in
tumorigenesis, tumor growth, metastasis, and prognosis has been achieved. The broad …

[PDF][PDF] The mechanisms of action of Tumor Treating Fields

JC Moser, E Salvador, K Deniz, K Swanson… - Cancer research, 2022 - AACR
Abstract Tumor Treating Fields (TTFields), a new modality of cancer treatment, are electric
fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment …

Tumor-treating fields in glioblastomas: past, present, and future

X Guo, X Yang, J Wu, H Yang, Y Li, J Li, Q Liu, C Wu… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most common malignant primary brain tumor.
Although the standard of care, including maximal resection, concurrent radiotherapy with …

[HTML][HTML] Reprogramming of glucose metabolism: the hallmark of malignant transformation and target for advanced diagnostics and treatments

Q Tang, S Wu, B Zhao, Z Li, Q Zhou, Y Yu… - Biomedicine & …, 2024 - Elsevier
Reprogramming of cancer metabolism has become increasingly concerned over the last
decade, particularly the reprogramming of glucose metabolism, also known as the" Warburg …

Permeabilizing cell membranes with electric fields

AA Aguilar, MC Ho, E Chang, KW Carlson, A Natarajan… - Cancers, 2021 - mdpi.com
Simple Summary The FDA recently approved a fourth approach (in addition to surgery,
radiation therapy, and chemotherapy) for treating glioblastoma; namely, tumor treating fields …

Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity …

Q Cao, A Hajosch, RE Kast, C Loehmann… - British Journal of …, 2024 - nature.com
Background Glioblastoma represents a brain tumor with a notoriously poor prognosis. First-
line therapy may include adjunctive Tumor Treating Fields (TTFields) which are electric …

[HTML][HTML] Current status of the preclinical evaluation of alternating electric fields as a form of cancer therapy

C Pohling, H Nguyen, E Chang, KE Schubert, Y Nie… - …, 2023 - Elsevier
Exposing cancer cells to alternating electric fields of 100-300 kHz frequency and 1-4 V/cm
strength has been shown to significantly reduce cancer growth in cell culture and in human …

[PDF][PDF] Anti-cancer mechanisms of action of therapeutic alternating electric fields (tumor treating fields [TTFields])

S Shams, CB Patel - Journal of molecular cell biology, 2022 - academic.oup.com
Despite improved survival outcomes across many cancer types, the prognosis remains grim
for certain solid organ cancers including glioblastoma and pancreatic cancer. Invariably in …

Tumor treating fields: a comprehensive overview of the underlying molecular mechanism

P Hong, N Kudulaiti, S Wu, J Nie… - Expert review of …, 2022 - Taylor & Francis
Introduction As a novel treatment modality, tumor treating fields (TTFields) exert low-
intensity, medium-frequency electric fields on tumor cells. TTFields' effectiveness and safety …

Tumor-Treating Fields: A fourth modality in cancer treatment, new practice updates

R Arvind, SR Chandana, MJ Borad… - Critical Reviews in …, 2021 - Elsevier
Although major innovations in treatment are advancing, cancer persists as one of the
leading causes of mortality. With the rising incidence of cancer and as we treat them …