Current progress and future perspectives of polypharmacology: From the view of non-small cell lung cancer
R Karuppasamy, S Veerappapillai, S Maiti… - Seminars in cancer …, 2021 - Elsevier
A pre-eminent subtype of lung carcinoma, Non-small cell lung cancer accounts for
paramount causes of cancer-associated mortality worldwide. Undeterred by the endeavour …
paramount causes of cancer-associated mortality worldwide. Undeterred by the endeavour …
Computational approaches for identifying potential inhibitors on targeting protein interactions in drug discovery
V Kanakaveti, A Shanmugam, C Ramakrishnan… - Advances in protein …, 2020 - Elsevier
In the era of big data, the interplay of artificial and human intelligence is the demanding job
to address the concerns involving exchange of decisions between both sides. Drug …
to address the concerns involving exchange of decisions between both sides. Drug …
Novel BH4-BCL-2 domain antagonists induce BCL-2-mediated apoptosis in triple-negative breast cancer
Simple Summary Our work has led to the identification of three novel BH4 mimetics, SM216,
SM396, and SM949, with nanomolar activities both in vitro and in vivo assays. SM396 binds …
SM396, and SM949, with nanomolar activities both in vitro and in vivo assays. SM396 binds …
Repurposing of phytocompounds-derived novel bioactive compounds possessing promising anticancer and cancer therapeutic efficacy through molecular docking …
Though considerable success has been achieved in modern decades through
chemotherapy, radiation, and surgery for efficient cancer therapy, cancers continue to be a …
chemotherapy, radiation, and surgery for efficient cancer therapy, cancers continue to be a …
[PDF][PDF] Novel BH4-BCL-2 Domain Antagonists Induce BCL-2-Mediated Apoptosis in Triple-Negative Breast Cancer.
V Kanakaveti, S Ramasamy, R Kanumuri… - …, 2022 - pdfs.semanticscholar.org
Targeting the challenging tumors lacking explicit markers and predictors for chemosensitivity
is one of the major impediments of the current cancer armamentarium. Triple-negative …
is one of the major impediments of the current cancer armamentarium. Triple-negative …
[引用][C] Prospects of utilizing computational techniques for the treatment of human diseases
A Nayarisseri - Current topics in medicinal chemistry, 2019 - ingentaconnect.com
Drugs play an important role in treating life-threatening diseases. In most cases these drugs
act as inhibitors, as well as enhancers for a certain protein. The protein often participates in …
act as inhibitors, as well as enhancers for a certain protein. The protein often participates in …