Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Background Studies using positron emission tomography to image striatal dopamine
function, have demonstrated that individuals with schizophrenia display increases in …

Context Current drug treatments for schizophrenia are inadequate for many patients, and
despite 5 decades of drug discovery, all of the treatments rely on the same mechanism …

Background A lack of a sufficiently large sample at single sites causes poor generalizability
in automatic diagnosis classification of heterogeneous psychiatric disorders such as …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …

OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this
overview is to link the neurobiology (brain), the phenomenological experience (mind), and …

In 1996 Joseph LeDoux's The Emotional Brain presented a revelatory examination of the
biological bases of our emotions and memories. Now, the world-renowned expert on the …

To the Editor: Approximately a third of patients with schizophrenia show a limited response
to antipsychotic medication (1). This might be due to distinct neurochemical abnormalities in …