In a society where physical activity is limited and food supply is abundant, metabolic
diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …

Interpreting the effects of genetic variants is key to understanding individual susceptibility to
disease and designing personalized therapeutic approaches. Modern experimental …

Background Correlation networks are increasingly being used in bioinformatics applications.
For example, weighted gene co-expression network analysis is a systems biology method …

In many applications, one is interested in determining which of the properties of a network
module change across conditions. For example, to validate the existence of a module, it is …

A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus mapping and …

Mitochondrial morphology is regulated by the balance between two counteracting
mitochondrial processes of fusion and fission. There is significant evidence suggesting a …

Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a
rapidly expanding tumor mass, obese adipose tissue becomes hypoxic due to the inability of …

The molecular biology revolution led to an intense focus on the study of interactions
between DNA, RNA and protein biosynthesis in order to develop a more comprehensive …