Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Choosing an animal model for the study of Huntington's disease

MA Pouladi, AJ Morton, MR Hayden - Nature Reviews Neuroscience, 2013 - nature.com
Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Maternal diet disrupts the placenta–brain axis in a sex-specific manner

AM Ceasrine, BA Devlin, JL Bolton, LA Green… - Nature …, 2022 - nature.com
High maternal weight is associated with detrimental outcomes in offspring, including
increased susceptibility to neurological disorders such as anxiety, depression and …

Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice

I Gracia-Rubio, M Moscoso-Castro, OJ Pozo… - Progress in Neuro …, 2016 - Elsevier
Early life experiences play a key role in brain function and behaviour. Adverse events during
childhood are therefore a risk factor for psychiatric disease during adulthood, such as mood …

Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease

C Gubert, G Kong, C Costello, CD Adams… - Brain, Behavior, and …, 2024 - Elsevier
Huntington's disease (HD) is a neurodegenerative disorder involving psychiatric, cognitive
and motor deficits, as well as peripheral symptoms, including gastrointestinal dysfunction …

N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

DJ Wright, T Renoir, ZM Smith, AE Frazier… - Translational …, 2015 - nature.com
Huntington's disease (HD) is a neurodegenerative disorder, involving psychiatric, cognitive
and motor symptoms, caused by a CAG-repeat expansion encoding an extended …

Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease

C Mo, AJ Hannan, T Renoir - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …

Sexual dimorphism in neurodegenerative diseases and in brain ischemia

T Zalewska, P Pawelec, K Ziabska, M Ziemka-Nalecz - Biomolecules, 2022 - mdpi.com
Epidemiological studies and clinical observations show evidence of sexual dimorphism in
brain responses to several neurological conditions. It is suggested that sex-related …

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

P Pla, S Orvoen, F Saudou, DJ David… - Frontiers in behavioral …, 2014 - frontiersin.org
Huntington's disease (HD) is a neurodegenerative disorder that is best known for its effect
on motor control. Mood disturbances such as depression, anxiety, and irritability also have a …