In response to varying stress signals, the p53 tumor suppressor is able to promote repair,
survival, or elimination of damaged cells–processes that have great relevance to organismal …

Diabetic retinopathy (DR) is one of the most common microvascular complications of
diabetes and is the leading cause of blindness in young adults. Oxidative stress has been …

Age-related macular degeneration (AMD) is the leading cause of blindness among older
adults. It has been suggested that mitochondrial defects in the retinal pigment epithelium …

Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …

The prevalence of diabetes mellitus (DM), has been increasing worldwide. Diabetic
retinopathy (DR) is the most common microvascular complication in diabetes. It is a …

Understanding the mechanisms that underlie age-related macular degeneration (AMD) has
led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have …

The sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-
dependent histone deacetylases that helps regulate the lifespan of diverse organisms. The …

In this review we will discuss the links between autophagy, a mechanism involved in the
maintenance of cellular homeostasis and controlling cellular waste management, and the …

Degeneration of retinal pigment epithelial (RPE) cells is a clinical hallmark of age-related
macular degeneration (AMD), the leading cause of blindness among aged people in the …

ABSTRACT Introduction: Age-related Macular Degeneration (AMD), a retinal
neurodegenerative disease is the most common cause of blindness among the elderly in …