Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including
antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities …

Type II topoisomerase (Top2) poisoning therapy is used to treat a broad range of cancers via
induction of double strand breaks (DSBs) in cells undergoing replication and transcription …

Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive
oxygen species (ROS) to kill cancer cells. However, the effectiveness of PDT is greatly …

Simple Summary The word “model” can be used with different meanings and different
contexts, like a model student, clay models or a model railway. In some cases, the context …

Multiplex Immunohistochemistry (mIHC) allows for the simultaneous detection of multiple
targets of interest in a single tissue section. Using this method it is therefore possible to …

Live bacterial therapeutics is gaining attention, especially for cancer therapy, because
anaerobic bacteria selectively grow inside the solid tumours. However, the effect of tumour …

Cellular target engagement technologies enable quantification of intracellular drug binding;
however, simultaneous assessment of drug-associated phenotypes has proven challenging …

The effect of anti-angiogenic agents on tumor oxygenation has been in question for a
number of years, where both increases and decreases in tumor pO 2 have been observed …

The ability of a panel of camptothecin derivatives to access the tumor compartment was
evaluated to determine the mechanisms by which the architecture of solid tumors may act to …

3-(Aminoalkylamino)-1, 2, 4-benzotriazine-1, 4-dioxide-extended derivatives were
synthesized by the structural modification of 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide …