Kinetic and biophysical parameters of T cell receptor (TCR) and peptide: MHC (pMHC)
interaction define intrinsic factors required for T cell activation and differentiation. Although …

One of the main goals in T cell biology has been to investigate how TCR recognition of
peptide: MHC (pMHC) determines T cell phenotype and fate. Ag recognition is required to …

We have recently shown that two-dimensional (2D) and force-regulated kinetics of TCR–
peptide-bound MHC class I (pMHC-I) interactions predict responses of CD8+ T cells. To test …

Tissue-resident memory T (T RM) cells serve as vanguards of antimicrobial host defense in
nonlymphoid tissues, particularly at barrier epithelia and in organs with nonrenewable cell …

A robust primary immune response has been correlated with the precursor number of
antigen-specific T cells, as identified using peptide MHCII tetramers. However, these …

Cytotoxic T cells (CTLs) bind to peptides presented by MHC I (pMHC) through T cell
receptors of various affinities. Low-affinity CTLs are important for the control of intracellular …

TCR affinity for peptide MHC dictates the functional efficiency of T cells and their propensity
to differentiate into effectors and form memory. However, in the context of chronic infections …

Expression of programmed death 1 (PD-1) on CD8 T cells promotes T cell exhaustion during
chronic Ag exposure. During acute infections, PD-1 is transiently expressed and has the …

T cells are critical for a functioning adaptive immune response and a strong correlation
exists between T cell responses and T cell receptor (TCR): peptide-loaded MHC (pMHC) …

The diversification of the immune response induced by an antigen to new T-cell and/or
antibody specificities during the course of an autoimmune disease is known as “epitope …