[HTML][HTML] The role of bacterial vaccines in the fight against antimicrobial resistance: an analysis of the preclinical and clinical development pipeline
I Frost, H Sati, P Garcia-Vello… - The Lancet …, 2023 - thelancet.com
Vaccines can be highly effective tools in combating antimicrobial resistance as they reduce
infections caused by antibiotic-resistant bacteria and antibiotic consumption associated with …
infections caused by antibiotic-resistant bacteria and antibiotic consumption associated with …
[HTML][HTML] Genomics for public health and international surveillance of antimicrobial resistance
Historically, epidemiological investigation and surveillance for bacterial antimicrobial
resistance (AMR) has relied on low-resolution isolate-based phenotypic analyses …
resistance (AMR) has relied on low-resolution isolate-based phenotypic analyses …
[HTML][HTML] Intrafamilial exposure to SARS-CoV-2 associated with cellular immune response without seroconversion, France
F Gallais, A Velay, C Nazon, MJ Wendling… - Emerging infectious …, 2021 - ncbi.nlm.nih.gov
We investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific
antibodies and T-cell responses against SARS-CoV-2 and human coronavirus (HCoV) 229E …
antibodies and T-cell responses against SARS-CoV-2 and human coronavirus (HCoV) 229E …
[HTML][HTML] International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact
Background Pneumococcal conjugate vaccines have reduced the incidence of invasive
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a …
[HTML][HTML] Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
[HTML][HTML] Effect of pneumococcal conjugate vaccines and SARS-CoV-2 on antimicrobial resistance and the emergence of Streptococcus pneumoniae serotypes with …
J Sempere, M Llamosí, BL Ruiz, I Del Rio… - The Lancet …, 2022 - thelancet.com
Background Epidemiological studies are necessary to explore the effect of current
pneumococcal conjugate vaccines (PCVs) against antibiotic resistance, including the rise of …
pneumococcal conjugate vaccines (PCVs) against antibiotic resistance, including the rise of …
Community-acquired bacterial meningitis
Progress has been made in the prevention and treatment of community-acquired bacterial
meningitis during the past three decades but the burden of the disease remains high …
meningitis during the past three decades but the burden of the disease remains high …
[HTML][HTML] Sugar-coated killer: serotype 3 pneumococcal disease
JN Luck, H Tettelin, CJ Orihuela - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Capsular polysaccharide (CPS), which surrounds the bacteria, is one of the most significant
and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents …
and multifaceted contributors to Streptococcus pneumoniae virulence. Capsule prevents …
[HTML][HTML] The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi
Streptococcus pneumoniae causes substantial mortality among children under 5-years-old
worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing …
worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing …
Improved prediction of bacterial genotype-phenotype associations using interpretable pangenome-spanning regressions
Discovery of genetic variants underlying bacterial phenotypes and the prediction of
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …
phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics …