Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic
syndrome and particularly implicates innate immunity in the development of complications …

This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Diabetes (type 2) and sensorineural hearing loss are common health problems manifested
with ageing. While both type 1 and type 2 diabetes have been associated with hearing loss …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to
study axon regeneration. Whereas regeneration and functional recovery occurs after …

With the deepening of the researches on uric acid, especially in the study of metabolic
diseases, uric acid has been found to be closely related to obesity, metabolic syndrome …

In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have
largely been explored in the context of pain, nerve injury, and repair. However, we …

The blood barriers of the nervous system protect neural environments but can hinder
therapeutic accessibility. The blood-brain barrier (BBB) is well characterized, consisting of …

Vascular basement membrane (BM) thickening has been hailed over half a century as the
most prominent histological lesion in diabetic microangiopathy, and represents an early …