Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic
fatal outbreaks in humans and non-human primates have been reported. However, the …

Background Mother-to-child transmission of HIV-1 remains a significant problem in the
resource-constrained settings where anti-retroviral therapy is still not widely available …

Background The third variable loop (V3) of the HIV-1 gp120 surface protein is a major
determinant of cellular co-receptor binding. However, HIV-1 can also modulate its tropism …

Background The HIV-1 subtype B epidemic in Brazil is peculiar because of the high
frequency of isolates having the GWGR tetramer at V3 loop region. It has been suggested …

The majority of studies have characterized the tropism of HIV-1 subtype-B isolates, but little
is known about the determinants of tropism in other subtypes. So, the goal of the present …

The characteristics of intra-host human immunodeficiency virus type 1 (HIV-1) env evolution
were evaluated in untreated HIV-1-infected subjects with different patterns of disease …

Background The level of viral diversity in an HIV-infected individual can change during the
course of HIV infection, reflecting mutagenesis during viral replication and selection of viral …

One of most intriguing features of the HIV-1 subtype B epidemic in Brazil is the high
frequency of isolates exhibiting tryptophan (W) in the tetramer (GWGR) at the tip of the V3 …

Background: We used a novel high resolution melting (HRM) diversity assay to analyze HIV
diversity in Ugandan children (age 0.6–12.4 years) who were enrolled in an observational …

Abstract Background The human APOBEC3G (A3G) protein activity is associated with innate
immunity against HIV-1 by inducing high rates of guanosines to adenosines (G-to-A) …