The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research

A Pittig, M Treanor, RT LeBeau, MG Craske - … & Biobehavioral Reviews, 2018 - Elsevier
Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …

[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Activated Tryptophan-Kynurenine metabolic system in the human brain is associated with learned fear

MR Battaglia, C Di Fazio, S Battaglia - Frontiers in Molecular …, 2023 - frontiersin.org
Fear is widely recognized as a defensive emotion that has developed as a consequence of
its adaptive function in protecting the entire animal kingdom from danger, ensuring the …

Fear extinction and relapse: state of the art

B Vervliet, MG Craske, D Hermans - Annual review of clinical …, 2013 - annualreviews.org
Exposure-based treatments for clinical anxiety generally are very effective, but relapse is not
uncommon. Likewise, laboratory studies have shown that conditioned fears are easy to …

Rethinking extinction

JE Dunsmoor, Y Niv, N Daw, EA Phelps - Neuron, 2015 - cell.com
Extinction serves as the leading theoretical framework and experimental model to describe
how learned behaviors diminish through absence of anticipated reinforcement. In the past …

Preventing the return of fear in humans using reconsolidation update mechanisms

D Schiller, MH Monfils, CM Raio, DC Johnson… - Nature, 2010 - nature.com
Recent research on changing fears has examined targeting reconsolidation. During
reconsolidation, stored information is rendered labile after being retrieved. Pharmacological …

Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories

MH Monfils, KK Cowansage, E Klann, JE LeDoux - science, 2009 - science.org
Dysregulation of the fear system is at the core of many psychiatric disorders. Much progress
has been made in uncovering the neural basis of fear learning through studies in which …

The body and the brain: Measuring skin conductance responses to understand the emotional experience

GI Christopoulos, MA Uy… - Organizational Research …, 2019 - journals.sagepub.com
In this article, we introduce the method of measuring skin conductance responses (SCR)
reflecting peripheral (bodily) signals associated with emotions, decisions, and eventually …

Neuronal circuits of fear extinction

C Herry, F Ferraguti, N Singewald… - European journal of …, 2010 - Wiley Online Library
Fear extinction is a form of inhibitory learning that allows for the adaptive control of
conditioned fear responses. Although fear extinction is an active learning process that …

Reconsolidation/destabilization, extinction and forgetting of fear memory as therapeutic targets for PTSD

S Kida - Psychopharmacology, 2019 - Springer
Post-traumatic stress disorder (PTSD) is a psychiatric disorder associated with memories of
traumatic experiences. Conditioned fear memory, a representative model of traumatic …