Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

X Chen, C Shi, M He, S Xiong, X Xia - Signal transduction and targeted …, 2023 - nature.com
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy

QR Li, HY Xu, RT Ma, YY Ma, MJ Chen - Diabetes Therapy, 2024 - Springer
Diabetes mellitus (DM) significantly impairs patients' quality of life, primarily because of its
complications, which are the leading cause of mortality among individuals with the disease …

Stabilization of glutathione redox dynamics and CYP2E1 by green synthesized Moringa oleifera-mediated zinc oxide nanoparticles against acrylamide induced …

H Mahfouz, N Dahran, AAR Mohamed… - Food and Chemical …, 2023 - Elsevier
The terrible reality is that acrylamide (AA) is a common food contaminant found in a wide
variety of commonly consumed foods. This research involves the advancement of a more …

Enhancement of biochemical and genomic pathways through lycopene-loaded nano-liposomes: Alleviating insulin resistance, hepatic steatosis, and autophagy in …

GA Salem, AAR Mohamed, SI Khater, AE Noreldin… - Gene, 2023 - Elsevier
Non-alcoholic fatty liver (NAFL) is a prevalent hepatic disorder of global significance that can
give rise to severe complications. This research endeavor delves into the potential of nano …

[HTML][HTML] Liposome-encapsulated Berberine alleviates liver injury in type 2 diabetes via promoting AMPK/mTOR-mediated autophagy and reducing ER stress …

SI Khater, TN Almanaa, DMA Fattah, T Khamis… - Antioxidants, 2023 - mdpi.com
In the advanced stages of type 2 diabetes mellitus (T2DM), diabetic liver damage is a
common complication that can devastate a patient's quality of life. The present study …

Luteolin/ZnO nanoparticles attenuate neuroinflammation associated with diabetes via regulating MicroRNA‐124 by targeting C/EBPA

EM Moustafa, FSM Moawed… - Environmental …, 2023 - Wiley Online Library
Objective The most prevalent brain‐specific microRNA, MicroRNA‐124, exhibits anti‐
inflammatory properties. Luteolin nano‐formulation with Zn oxide in the form of L/ZnO NPs …

Autophagy Activation Promoted by Pulses of Light and Phytochemicals Counteracting Oxidative Stress during Age-Related Macular Degeneration

R Pinelli, M Ferrucci, F Biagioni, C Berti, VV Bumah… - Antioxidants, 2023 - mdpi.com
The seminal role of autophagy during age-related macular degeneration (AMD) lies in the
clearance of a number of reactive oxidative species that generate dysfunctional …

Understanding fenpropathrin-induced pulmonary toxicity: What apoptosis, inflammation, and pyreptosis reveal analyzing cross-links at the molecular …

AAR Mohamed, YM Abd-Elhakim, AE Noreldin… - Food and Chemical …, 2024 - Elsevier
Fenpropathrin (FN), a pyrethroid has been linked to potential pulmonary toxic effects to
humans via incident direct or indirect ingestion. Thus, we aimed to the investigate the …

[HTML][HTML] Natural Autophagy Activators to Fight Age-Related Diseases

VM Mundo Rivera, JR Tlacuahuac Juárez… - Cells, 2024 - mdpi.com
The constant increase in the elderly population presents significant challenges in
addressing new social, economic, and health problems concerning this population. With …

Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the …

BS Alotaibi, A Abdel-Rahman Mohamed… - Frontiers in …, 2024 - frontiersin.org
Introduction: The synthetic pyrethroid derivative fenpropathrin (FNE), a commonly used
insecticide, has been associated with various toxic effects in mammals, particularly …