The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …

Silks are protein-based fibers made by arthropods for a variety of task-specific applications.
In this article, we review the key features of silk proteins. This article initially focuses on the …

Cellular processes often depend on interactions between proteins and the formation of
macromolecular complexes. The impairment of such interactions can lead to deregulation of …

Engineers routinely design systems to be modular and symmetric in order to increase
robustness to perturbations and to facilitate alterations at a later date. Biological structures …

Protein structures are essential to understanding cellular processes in molecular detail.
While advances in artificial intelligence revealed the tertiary structure of proteins at scale …

Abstract The RCSB Protein Data Bank (RCSB PDB, http://www. rcsb. org) provides access to
3D structures of biological macromolecules and is one of the leading resources in biology …

We describe a general computational method for designing proteins that self-assemble to a
desired symmetric architecture. Protein building blocks are docked together symmetrically to …

Modeling the impact of amino acid mutations on protein-protein interaction plays a crucial
role in protein engineering and drug design. In this study, we develop GeoPPI, a novel …

Proteomics has been revolutionized by large protein language models (PLMs), which learn
unsupervised representations from large corpora of sequences. These models are typically …

The self-association of proteins into symmetric complexes is ubiquitous in all kingdoms of
life,,,,,. Symmetric complexes possess unique geometric and functional properties, but their …