Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y Xie… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

LncRNA MAGI2-AS3 is regulated by BRD4 and promotes gastric cancer progression via maintaining ZEB1 overexpression by sponging miR-141/200a

D Li, J Wang, M Zhang, X Hu, J She, X Qiu… - … Therapy-Nucleic Acids, 2020 - cell.com
Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and tumor
progression. However, the biological function of most lncRNAs remains unknown in human …

A novel circular RNA, circFAT1 (e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus

J Fang, H Hong, X Xue, X Zhu, L Jiang, M Qin, H Liang… - Cancer letters, 2019 - Elsevier
In the present study, two circular RNA (circRNA) expression profiles in paired gastric cancer
(GC) tissues from the GEO database were examined. We identified a novel circRNA …

[HTML][HTML] Notch and mTOR signaling pathways promote human gastric cancer cell proliferation

ES Hibdon, N Razumilava, TM Keeley, G Wong… - Neoplasia, 2019 - Elsevier
Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive
pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models …

Circular RNA hsa_circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506–5p/FOXO3 axis

J Lu, P Zhang, P Li, J Xie, J Wang, J Lin, Q Chen… - Biochemical and …, 2019 - Elsevier
Gastric cancer (GC) is still a major aggressive malignancy worldwide. While the importance
of circular RNAs (circRNAs) involved in carcinogenesis has gradually been acknowledged …

miRNA‐194 predicts favorable prognosis in gastric cancer and inhibits gastric cancer cell growth by targeting CCND1

J Wang, M Zhang, X Hu, J She, R Sun, S Qin… - FEBS open …, 2021 - Wiley Online Library
MicroRNAs (MiRNAs) play critical roles in regulating target gene expression and multiple
cellular processes in human cancer malignant progression. However, the function of miR …

Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer

EE Yörüker, M Keskin, CB Kulle… - Biomedical …, 2018 - spandidos-publications.com
Gastric cancer (GC) is among the most frequent malignant diseases. Despite advances in
treatment, the clinical outcome of patients with GC remains poor. The establishment of novel …

SEOM clinical guideline for the diagnosis and treatment of gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJA)(2019)

M Martín-Richard, A Carmona-Bayonas… - Clinical and …, 2020 - Springer
Gastric cancer (GC) is the fifth most common cancer worldwide with a varied geographic
distribution and an aggressive behavior. In Spain, it represents the sixth cause of cancer …

Synaptotagmin 11 scaffolds MKK7–JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis

BK Kim, DM Kim, H Park, SK Kim, MA Hwang… - Journal of Experimental …, 2022 - Springer
Background Identifying biomarkers related to the diagnosis and treatment of gastric cancer
(GC) has not made significant progress due to the heterogeneity of tumors. Genes involved …

Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy

Q Luo, Z Dong, W Xie, X Fu, L Lin, Q Zeng, Y Chen… - Cell Reports, 2023 - cell.com
Apatinib has been shown to clinically enhance anti-PD-1 immunotherapy for advanced
gastric cancer (GC). However, the complexity of GC immunosuppression remains a …