Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first
identified~ 25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring …

The adaptation of adenoviruses as gene delivery tools has resulted in the development of
high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or “gutless” …

Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is
essentially incurable and its resistance to therapy is attributed to a subpopulation of cells …

A single gene mutation can cause a number of human diseases that affect the quality of life.
Until the development of clustered regularly interspaced short palindromic repeats …

Chimeric antigen receptor (CAR) T‐cell therapy is a new successful treatment for refractory
B‐cell leukemia. Successful therapeutic outcome depends on long‐term expression of CAR …

Clinical success in T cell therapy has stimulated widespread efforts to increase safety and
potency and to extend this technology to solid tumors. Yet progress in cell therapy remains …

Degradation of plasmid DNA (pDNA) in the endosome compartment and its release to the
cytosol are the major hurdles for efficient gene transfection. This is generally addressed by …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy
with a poor prognosis and a dismal survival rate. Oncolytic virus (OV) is an anticancer …

Simple Summary The treatment of cancer has progressed greatly with the advent of
immunotherapy and gene therapy, including the use of nonreplicating adenoviral vectors to …

Helicobacter pylori neutrophil-activating protein (HP-NAP) is a major virulence factor
involved in H. pylori infection. HP-NAP can mediate antitumor effects by recruiting …