RNA-mediated epigenetic regulation of gene expression

D Holoch, D Moazed - Nature Reviews Genetics, 2015 - nature.com
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

RNA interference pathways in fungi: mechanisms and functions

SS Chang, Z Zhang, Y Liu - Annual review of microbiology, 2012 - annualreviews.org
RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses
small noncoding RNAs to mediate posttranscriptional/transcriptional gene silencing. The …

[HTML][HTML] A role for small RNAs in DNA double-strand break repair

W Wei, Z Ba, M Gao, Y Wu, Y Ma, S Amiard, CI White… - Cell, 2012 - cell.com
Eukaryotes have evolved complex mechanisms to repair DNA double-strand breaks (DSBs)
through coordinated actions of protein sensors, transducers, and effectors. Here we show …

Drosha drives the formation of DNA: RNA hybrids around DNA break sites to facilitate DNA repair

WT Lu, BR Hawley, GL Skalka, RA Baldock… - Nature …, 2018 - nature.com
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely
important for cell survival. RNA has been implicated in the resolution of DNA damage but the …

RNA interference in fungi: pathways, functions, and applications

Y Dang, Q Yang, Z Xue, Y Liu - Eukaryotic cell, 2011 - Am Soc Microbiol
Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and
genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The …

[HTML][HTML] Stalled spliceosomes are a signal for RNAi-mediated genome defense

PA Dumesic, P Natarajan, C Chen, IA Drinnenberg… - Cell, 2013 - cell.com
Using the yeast Cryptococcus neoformans, we describe a mechanism by which transposons
are initially targeted for RNAi-mediated genome defense. We show that intron-containing …

Neurospora crassa, a model system for epigenetics research

R Aramayo, EU Selker - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
The filamentous fungus Neurospora crassa has provided a rich source of knowledge on
epigenetic phenomena that would have been difficult or impossible to gain from other …

A small RNA response at DNA ends in Drosophila

KM Michalik, R Böttcher, K Förstemann - Nucleic acids research, 2012 - academic.oup.com
Small RNAs have been implicated in numerous cellular processes, including effects on
chromatin structure and the repression of transposons. We describe the generation of a …

The RNAi universe in fungi: a varied landscape of small RNAs and biological functions

S Torres-Martínez… - Annual Review of …, 2017 - annualreviews.org
RNA interference (RNAi) is a conserved eukaryotic mechanism that uses small RNA
molecules to suppress gene expression through sequence-specific messenger RNA …

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability

T Gall-Duncan, J Luo, CM Jurkovic, LA Fischer, K Fujita… - Cell, 2023 - cell.com
Expansions of repeat DNA tracts cause> 70 diseases, and ongoing expansions in brains
exacerbate disease. During expansion mutations, single-stranded DNAs (ssDNAs) form …