Identification of type 2 diabetes loci in 433,540 East Asian individuals
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
Genome structure variation analyses of peach reveal population dynamics and a 1.67 Mb causal inversion for fruit shape
Abstract Background Structural variations (SVs), a major resource of genomic variation, can
have profound consequences on phenotypic variation, yet the impacts of SVs remain largely …
have profound consequences on phenotypic variation, yet the impacts of SVs remain largely …
Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
Genetic factors underlying leukocyte telomere length (LTL) may provide insights into
telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of …
telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of …
Inversions encounter relaxed genetic constraints and balance birth and death of TPS genes in Curcuma
Evolutionary dynamics of inversion and its impact on biochemical traits are a puzzling
question. Here, we show abundance of inversions in three Curcuma species (turmeric …
question. Here, we show abundance of inversions in three Curcuma species (turmeric …
Evolutionary and functional impact of common polymorphic inversions in the human genome
C Giner-Delgado, S Villatoro, J Lerga-Jaso… - Nature …, 2019 - nature.com
Inversions are one type of structural variants linked to phenotypic differences and adaptation
in multiple organisms. However, there is still very little information about polymorphic …
in multiple organisms. However, there is still very little information about polymorphic …
The early-life exposome modulates the effect of polymorphic inversions on DNA methylation
Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play
important roles in evolution, environmental adaptation, and complex traits. We investigated …
important roles in evolution, environmental adaptation, and complex traits. We investigated …
Systems genetic analysis of inversion polymorphisms in the malaria mosquito Anopheles gambiae
Inversion polymorphisms in the African malaria vector Anopheles gambiae segregate along
climatic gradients of aridity. Despite indirect evidence of their adaptive significance, little is …
climatic gradients of aridity. Despite indirect evidence of their adaptive significance, little is …
Determining the impact of uncharacterized inversions in the human genome by droplet digital PCR
Despite the interest in characterizing genomic variation, the presence of large repeats at the
breakpoints hinders the analysis of many structural variants. This is especially problematic …
breakpoints hinders the analysis of many structural variants. This is especially problematic …
Progress in defining the genetic contribution to type 2 diabetes in individuals of East Asian ancestry
CN Spracklen, X Sim - Current Diabetes Reports, 2021 - Springer
Abstract Purpose of Review Prevalence of type 2 diabetes (T2D) and progression of
complications differ between worldwide populations. While obesity is a major contributing …
complications differ between worldwide populations. While obesity is a major contributing …
Hereditary multiple exostoses caused by a chromosomal inversion removing part of EXT1 gene
A Alexandrou, N Salameh, I Papaevripidou… - Molecular …, 2023 - Springer
Background Hereditary multiple exostoses (HME) is an autosomal dominant skeletal
disorder characterized by the development of multiple, circumscript and usually symmetric …
disorder characterized by the development of multiple, circumscript and usually symmetric …