Immunodominant SARS‐CoV‐2‐specific CD4+ and CD8+ T‐cell responses elicited by inactivated vaccines in healthy adults

J Ning, Q Wang, Y Chen, T He, F Zhang… - Journal of Medical …, 2023 - Wiley Online Library
Safety profiles and humoral responses to inactivated severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) vaccines have been previously assessed, but cellular immune …

Upregulated CD8+ MAIT cell differentiation and KLRD1 gene expression after inactivated SARS-CoV-2 vaccination identified by single-cell sequencing

X Dou, M Peng, R Jiang, W Li, X Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Background The primary strategy for reducing the incidence of COVID-19 is SARS-CoV-2
vaccination. Few studies have explored T cell subset differentiation and gene expressions …

Immune response stability to the SARS-CoV-2 mRNA vaccine booster is influenced by differential splicing of HLA genes

CB Santos-Rebouças, CS Ferreira, JS Nogueira… - Scientific Reports, 2024 - nature.com
Many molecular mechanisms that lead to the host antibody response to COVID-19 vaccines
remain largely unknown. In this study, we used serum antibody detection combined with …

Disturbance of Adaptive Immunity System Was Accompanied by a Decrease in Plasma Short-Chain Fatty Acid for Patients Hospitalized During SARS-CoV-2 Infection …

Z Liang, N Wang, C Fan, L Shang, Y Zhang… - Journal of …, 2023 - Taylor & Francis
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
lead to disorders of immune function and a decrease in the diversity of intestinal flora. We …

[HTML][HTML] Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis

C Cai, Y Huang, L Li, KK Miu, Z Wang, Y Deng… - International …, 2024 - Elsevier
Background Ankylosing spondylitis (AS) is a chronic autoimmune arthritis that mainly affects
spine joints. To date, the pathogenesis of AS remains unclear, although immune cells and …

Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic

T Urbanowicz, P Czub… - Journal of …, 2023 - mdpi.com
Introduction: The COVID-19 pandemic has changed the immunological status of the
population, indicating increased activation. The aim of the study was to compare the degree …

Immune features revealed by single‐cell RNA and single‐cell TCR/BCR sequencing in patients with rheumatoid arthritis receiving COVID‐19 booster vaccination

Y Fan, S Huang, D Wu, M Chu, J Zhao… - Journal of Medical …, 2024 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by SARS‐CoV‐2, have profoundly
affected human health. Booster COVID‐19 vaccines have demonstrated significant efficacy …

Analysing transcriptomic signatures and identifying potential genes for the protective effect of inactivated COVID-19 vaccines

H Chen, L Zhang, C Xu, X Shen, J Lou, S Wu - PeerJ, 2023 - peerj.com
Inactivated vaccines are one of the most effective strategies for controlling the coronavirus
disease 2019 (COVID-19) pandemic. However, the response genes for the protective effect …

Single-cell multiomics analysis reveals SARS-CoV-2 inactivated vaccine-induced trained immunity modulated by epigenetic remodeling

Z Zhang, R Wang, H Hu, T Zhou, W Zhou, X Jiang… - 2024 - researchsquare.com
Recent studies have revealed gene-expression signatures in response to vaccination;
however, the epigenetic regulatory mechanisms that are underlying vaccine-induced …

Single-cell multi-omics analysis revealing immune features of inactivated COVID-19 vaccination in systemic lupus erythematosus patients

Y Zheng, S Wang, X Zhou, S Qiao, X Zhao… - Science …, 2024 - pubmed.ncbi.nlm.nih.gov
Single-cell multi-omics analysis revealing immune features of inactivated COVID-19
vaccination in systemic lupus erythematosus patients Single-cell multi-omics analysis revealing …