The chemokine CXCL12/stromal cell-derived factor 1 alpha has first been described in the
immune system where it functions include chemotaxis for lymphocytes and macrophages …

Chemokines are a group of small, secreted molecules that signal through G protein-coupled
receptors to promote cell survival and proliferation and to provide directional guidance to …

Early or late pubertal onset affects up to 5% of adolescents and is associated with adverse
health and psychosocial outcomes. Self‐limited delayed puberty (DP) segregates …

Individuals with an inherited deficiency in gonadotropin-releasing hormone (GnRH) have
impaired sexual reproduction. Previous genetic linkage studies and sequencing of plausible …

Primary aldosteronism is the most frequent cause of secondary hypertension and is
associated with increased morbidity and mortality compared with hypertensive controls. The …

The CXCL12/CXCR4 signaling pathway is involved in the development of numerous
neuronal and non-neuronal structures. Recent work established that the atypical second …

Tangential migration is a mode of cell movement, which in the developing cerebral cortex, is
defined by displacement parallel to the ventricular surface and orthogonal to the radial glial …

Puberty in humans is defined as the period of becoming capable of reproducing. It is marked
by maturation of the genital organs, development of secondary sex characteristics …

Olfaction depends on lifelong production of sensory neurons from CXCR4 expressing
neurogenic stem cells. Signaling by CXCR4 depends on the concentration of CXCL12 …

Clinically, Microtubule-targeted agents–induced neuropathic pain hampers
chemotherapeutics for patients with cancer. Here, we found that application of paclitaxel or …