Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes

W Wu, Y Liu, S Zeng, Y Han, H Shen - Journal of hematology & oncology, 2021 - Springer
In this era of precision medicine, with the help of biomarkers, immunotherapy has
significantly improved prognosis of many patients with malignant tumor. Deficient mismatch …

Prognostic and predictive molecular markers in cholangiocarcinoma

S Pavicevic, S Reichelt, D Uluk, I Lurje, C Engelmann… - Cancers, 2022 - mdpi.com
Simple Summary Cholangiocarcinoma (CCA) is a heterogenous and aggressive
malignancy of the intra-and extrahepatic biliary tract, marked by a steeply rising incidence …

Financial performance of rural banks in Indonesia: A two-stage DEA approach

R Sukmana, SR Ajija, SCU Salama, A Hudaifah - Heliyon, 2020 - cell.com
This study aims to analyze the efficiency performance of conventional and Islamic rural
banks in Indonesia, specifically, Bank Perkreditan Rakyat (BPR) and Bank Pembiayaan …

[HTML][HTML] Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma

J Lin, XU Yang, J Long, S Zhao, J Mao… - … surgery and nutrition, 2020 - ncbi.nlm.nih.gov
Background A therapeutic strategy involving combined treatment with lenvatinib plus
pembrolizumab (LEP) has demonstrated a relatively high antitumor response in several …

The value of platelet-to-lymphocyte ratio as a prognostic marker in cholangiocarcinoma: a systematic review and meta-analysis

D Liu, Z Czigany, LR Heij, SAW Bouwense, R van Dam… - Cancers, 2022 - mdpi.com
Simple Summary Platelet-to-lymphocyte ratio has shown prognostic value in several
malignancies; however, its role in cholangiocarcinoma remains to be determined. Therefore …

PNOC expressed by B cells in cholangiocarcinoma was survival related and LAIR2 could be a T cell exhaustion biomarker in tumor microenvironment …

Z Chen, M Yu, J Yan, L Guo, B Zhang, S Liu… - Frontiers in …, 2021 - frontiersin.org
Background Cholangiocarcinoma was a highly malignant liver cancer with poor prognosis,
and immune infiltration status was considered an important factor in response to …

The prognostic value of neutrophil-to-lymphocyte ratio in cholangiocarcinoma: a systematic review and meta-analysis

D Liu, LR Heij, Z Czigany, E Dahl, M Dulk, SA Lang… - Scientific Reports, 2022 - nature.com
The neutrophil-to-lymphocyte ratio (NLR) is used as biomarker in malignant diseases
showing significant association with poor oncological outcomes. The main research …

Latest evidence on immunotherapy for cholangiocarcinoma

X Guo, W Shen - Oncology letters, 2020 - spandidos-publications.com
Cholangiocarcinoma (CCA) is a type of aggressive tumor that involves the intrahepatic,
perihilar and distal biliary tree, and is usually diagnosed at an advanced stage. The …

PARP inhibitors in biliary tract cancer: a new kid on the block?

AD Ricci, A Rizzo, C Bonucci, N Tober, A Palloni… - Medicines, 2020 - mdpi.com
Poly adenosine diphosphate-ribose polymerase inhibitors (PARPi) represent an effective
therapeutic strategy for cancer patients harboring germline and somatic aberrations in DNA …

Immunotherapy for cholangiocarcinoma: a 2021 update

N Charalampakis, G Papageorgiou, S Tsakatikas… - …, 2021 - Taylor & Francis
Cholangiocarcinoma (CCA) is a rare malignancy with generally dismal prognosis.
Immunotherapy has revolutionized the management of cancer patients during the last …