Among the age-dependent protein aggregation disorders, nine neurodegenerative diseases
are caused by expansions of CAG repeats encoding polyglutamine (polyQ) tracts. We …

Curcumin, a nontoxic, naturally occurring polyphenol, has been recently proposed for the
management of neurodegenerative and neurological diseases. However, a discrepancy …

Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

Huntington's disease (HD) is one of an increasing number of neurodegenerative disorders
caused by a CAG/polyglutamine repeat expansion. Mice have been generated that are …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

We have identified a novel gene containing CAG repeats and mapped it to chromosome
14q32. 1, the genetic locus for Machado-Joseph disease (MJD). In normal individuals the …

The discovery that expansion of unstable repeats can cause a variety of neurological
disorders has changed the landscape of disease-oriented research for several forms of …

Targeted Disruption of the Huntington's Disease Gene Results in Embryonic Lethality and
Behavioral and Morphological Changes in Page 1 Cell, Vol. 81,811-823, June 2, 1995 …

The etiology of the selective neuronal death that occurs in Huntington's disease (HD) is
unknown. Several lines of evidence implicate the involvement of energetic defects and …

The expansion of GAG triplet repeats in the translated region of the human HD gene,
encoding a protein (huntingtin) of unknown function, is a dominant mutation leading to …