The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …

Abstract α-Synuclein is an abundantly expressed neuronal protein that is at the center of
focus in understanding a group of neurodegenerative disorders called α-synucleinopathies …

The prototype of transmissible neurodegenerative proteinopathies is prion diseases,
characterized by aggregation of abnormally folded conformers of the native prion protein. A …

Inappropriate use of pesticides has globally exposed mankind to a number of health
hazards. Still their production is rising at the rate of 11% annually and, has already …

Formation and aggregation of misfolded proteins in the central nervous system (CNS) is a
key hallmark of several age-related neurodegenerative diseases, including Parkinson's …

Alzheimer's and Parkinson's diseases are the most prevalent neurodegenerative diseases
that generate important health-related direct and indirect socio-economic costs. They are …

The analysis of contacts is a powerful tool to understand biomolecular function in a series of
contexts, from the investigation of dynamical behavior at equilibrium to the study of …

The accumulation and deposition of α-synuclein aggregates in brain tissue is the main event
in the pathogenesis of different neurodegenerative disorders grouped under the term of …