Eukaryotic cells use the endoplasmic reticulum (ER)-to-Golgi membrane pathway for the
secretion of the vast majority of secretory proteins. This process is initiated by signal-peptide …

Growth factors belonging to the FGF family play important roles in tissue and organ repair
after trauma. In this review, I discuss the regulation by FGFs of the aspects of cellular …

Simple Summary The prognosis of brain metastasis is extremely poor, partly because of the
concurrence of multiple brain lesions and their limited access to current systemic therapies …

FGF12 belongs to a subfamily of FGF proteins called FGF homologous factors (FHFs), which
until recently were thought to be non-signaling intracellular proteins. Our recent studies have …

The impact of gene loss on the diversification of taxa and the emergence of evolutionary
innovations remains poorly understood. Here, our investigation on the evolution of the …

Extracellular proteins devoid of signal peptides use nonclassical secretion mechanisms for
their export. These mechanisms are independent of the endoplasmic reticulum and Golgi …

Abstract Anoctamin 6 (ANO6/TMEM16F) is a recently identified membrane protein that has
both phospholipid scramblase activity and anion channel function activated by relatively …

Abstract Mutant superoxide dismutase 1 (SOD1) can be constitutively released from motor
neurons and transmitted to naïve motor neurons to promote the progression of amyotrophic …

ABSTRACT FGF1 is a nonclassically released growth factor that regulates carcinogenesis,
angiogenesis, and inflammation. In vitro and in vivo, FGF1 export is stimulated by cell stress …

Annexin A2 (AnxA2) is a calcium-and lipid-binding protein involved in neuroendocrine
secretion where it participates in the formation and/or stabilization of lipid micro-domains …