Male germ cells, the repository cells of the genome, comprise several successive
developmental stages starting in the embryo and ending up with the spermatozoon …

The importance of the gene regulation roles of small non-coding RNAs and their protein
partners is of increasing focus. In this paper, we reviewed three main small RNA species …

The switch from mitosis to meiosis is a unique feature of germ cell development. In
mammals, meiotic initiation requires retinoic acid (RA), which activates meiotic inducers …

Vitamin A is required for male fertility and normal spermatogenesis. Retinoic acid (RA), an
active metabolite of vitamin A, is necessary for spermatogonial maturation and proper entry …

Gamete failure-derived infertility affects millions of people worldwide; for many patients,
gamete donation by unrelated donors is the only available treatment. Embryonic stem cells …

Spermatogonial stem cells are required for the initiation of spermatogenesis and the
continuous production of sperm. In addition, they can acquire pluripotency and differentiate …

Piwil2, a member of AGO/PIWI family of proteins, has been reported to be expressed in
precancerous stem cells (pCSCs), tumor cell lines and various types of human cancers …

Germ cells must develop along distinct male or female paths to produce spermatozoa or
eggs required for sexual reproduction. Male germline stem cells maintain spermatogenesis …

In this study, isolated spermatogonial stem cells (SSCs) and Sertoli cells using enzymatic
digestion from patients with maturation arrest of spermatogenesis were grown in Dulbecco's …

Piwi proteins have been implicated in germ cell proliferation, differentiation, germline stem
cell maintenance and transposon control in germline from Drosophila to mammals. The Piwi …