Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease
J Nowell, E Blunt, P Edison - Molecular Psychiatry, 2023 - nature.com
Despite an ever-growing prevalence and increasing economic burden of Alzheimer's
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …
Neurogenesis in aging and age-related neurodegenerative diseases
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …
adult brain, declines in an age-dependent manner and is one potential target for extending …
Physiological and functional basis of dopamine receptors and their role in neurogenesis: possible implication for Parkinson's disease
Dopamine controls various physiological functions in the brain and periphery by acting on its
receptors D1, D2, D3, D4, and D5. Dopamine receptors are G protein–coupled receptors …
receptors D1, D2, D3, D4, and D5. Dopamine receptors are G protein–coupled receptors …
The role of lipids in Parkinson's disease
H Xicoy, B Wieringa, GJM Martens - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …
Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: a secondary analysis of the …
D Athauda, S Gulyani, H kumar Karnati, Y Li… - JAMA …, 2019 - jamanetwork.com
Importance Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was
recently found to have beneficial effects on motor function in a randomized, placebo …
recently found to have beneficial effects on motor function in a randomized, placebo …
Fecal microbiota transplantation from aged mice render recipient mice resistant to MPTP-induced nigrostriatal degeneration via a neurogenesis-dependent but …
CM Qiao, Y Zhou, W Quan, XY Ma, LP Zhao, Y Shi… - …, 2023 - Springer
Accumulating data support a crucial role of gut microbiota in Parkinson's disease (PD).
However, gut microbiota vary with age and, thus, will affect PD in an age-dependent, but …
However, gut microbiota vary with age and, thus, will affect PD in an age-dependent, but …
Abnormal hippocampal neurogenesis in Parkinson's disease: relevance to a new therapeutic target for depression with Parkinson's disease
J Lim, Y Bang, HJ Choi - Archives of pharmacal research, 2018 - Springer
Parkinson's disease (PD) is a common progressive neurodegenerative disorder
characterized by motor dysfunction, including bradykinesia, tremor, rigidity, and postural …
characterized by motor dysfunction, including bradykinesia, tremor, rigidity, and postural …
Dopamine D1 receptor activation improves adult hippocampal neurogenesis and exerts anxiolytic and antidepressant-like effect via activation of Wnt/β-catenin …
Parkinson's disease (PD) is primarily characterized by midbrain dopamine depletion.
Dopamine acts through dopamine receptors (D1 to D5) to regulate locomotion, motivation …
Dopamine acts through dopamine receptors (D1 to D5) to regulate locomotion, motivation …
Dopaminergic signaling as a plausible modulator of astrocytic toll-like receptor 4: a crosstalk between neuroinflammation and cognition
Neuroinflammation is one of the major pathological factors leading to Alzheimer's disease
(AD). The role of microglial cells in neuroinflammation associated with AD has been known …
(AD). The role of microglial cells in neuroinflammation associated with AD has been known …
Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson's Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of …
CM Qiao, WY Huang, Y Zhou, W Quan, GY Niu, T Li… - Brain Sciences, 2024 - mdpi.com
Increasing evidence suggests that the gut microbiota may represent potential strategies for
Parkinson's disease (PD) treatment. Our previous research revealed a decreased …
Parkinson's disease (PD) treatment. Our previous research revealed a decreased …