Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

The e rythropoietin-p roducing h epatocellular carcinoma (Eph) receptor tyrosine kinase
family plays important roles in developmental processes, adult tissue homeostasis, and …

The cell-biological program termed the epithelial–mesenchymal transition (EMT) confers on
cancer cells mesenchymal traits and an ability to enter the cancer stem cell (CSC) state …

Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Alzheimer's disease (AD), characterized by cognitive decline, has emerged as a disease of
synaptic failure. The present study reveals an unanticipated role of erythropoietin-producing …

Eph receptor tyrosine kinases and their ephrin ligands are involved in various signalling
pathways and mediate critical steps of a wide variety of physiological and pathological …

The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity
and synapse loss. Here, we show that amyloid-β oligomers (AβOs) activate the c-Abl kinase …

Purpose Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in
adults. It is almost invariably lethal within a few years after the onset of symptoms. No …

Alzheimer's disease (AD) is characterized by progressive memory loss and dementia. The
strong correlation between cognitive decline and the loss of synapses supports the idea that …

Fragment-based ligand design (FBLD) approaches have become more widely used in drug
discovery projects from both academia and industry, and are even often preferred to …