Emerging targets in type 2 diabetes and diabetic complications

S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling

L Thines, FJ Roushar, AC Hedman, DB Sacks - Journal of Cell Biology, 2023 - rupress.org
The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …

Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics

H Zhong, H Ren, Y Lu, C Fang, G Hou, Z Yang… - …, 2019 - thelancet.com
Background The gut microbiota plays important roles in modulating host metabolism.
Previous studies have demonstrated differences in the gut microbiome of T2D and …

Adipose cell size changes are associated with a drastic actin remodeling

B Hansson, B Morén, C Fryklund, L Vliex… - Scientific Reports, 2019 - nature.com
Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy
metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing …

Akt scaffold proteins: the key to controlling specificity of Akt signaling

F Bao, P Hao, S An, Y Yang, Y Liu… - … of Physiology-Cell …, 2021 - journals.physiology.org
The phosphatidylinositol 3-kinase-Akt signaling pathway plays an essential role in
regulating cell proliferation and apoptosis. Akt kinase is at the center of this signaling …

Role of IQ motif-containing GTPase-activating proteins in hepatocellular carcinoma

Q Dai, Q Ain, M Rooney, F Song, A Zipprich - Frontiers in Oncology, 2022 - frontiersin.org
IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins,
including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by …

IQGAP1 binds AMPK and is required for maximum AMPK activation

AC Hedman, Z Li, L Gorisse, S Parvathaneni… - Journal of Biological …, 2021 - ASBMB
AMP-activated protein kinase (AMPK) is a fundamental component of a protein kinase
cascade that is an energy sensor. AMPK maintains energy homeostasis in the cell by …

IQGAP1 is a phosphotyrosine-regulated scaffold for SH2-containing proteins

L Thines, Z Li, DB Sacks - Cells, 2023 - mdpi.com
The scaffold protein IQGAP1 associates with over 150 interactors to influence multiple
biological processes. The molecular mechanisms that underly spatial and temporal …

Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase

S Dong, S Baranwal, A Garcia… - Journal of Biological …, 2017 - ASBMB
Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting
interactions with several protein partners. To explore the physiological importance of Nisch …

Development of insulin resistance in Nischarin mutant female mice

S Dong, M Blüher, Y Zhang, H Wu… - International Journal of …, 2019 - nature.com
Abstract Background/Objectives NISCH–STAB1 is a newly identified locus correlated to
human waist–hip ratio (WHR), which is a risk indicator of developing obesity-associated …