Phospholipid scramblase activity is involved in the collapse of phospholipid (PL) asymmetry
at the plasma membrane leading to externalization of phosphatidylserine. This activity is …

Human phospholipid scramblases (hPLSCRs) are a family of four homologous single pass
transmembrane proteins (hPLSCR1-4) initially identified as the proteins responsible for Ca …

Motivation Structural studies of TM domains of single-spanning (bitopic) membrane proteins
are impeded by their instability, flexibility and heterogeneity. The new computational method …

The mechanisms of Pb (II) toxicity have been studied in human red blood cells using
confocal microscopy, immunolabeling, fluorescence-activated cell sorting and atomic force …

Human phospholipid scramblase 1 (SCR) catalyzes phospholipid transmembrane (flip-flop)
motion. This protein is assumed to bind the membrane hydrophobic core through a …

Human phospholipid scramblase 1 (hPLSCR1), a type II integral class membrane protein, is
known to mediate bidirectional scrambling of phospholipids in a Ca 2+-dependent manner …

Blood ultrafiltration in nephrons critically depends on specialized intercellular junctions
between podocytes, named slit diaphragms (SDs). Here, by studying a homologous …

Recent studies highlight the emerging role of lipids as important messengers in malaria
parasite biology. In an attempt to identify interacting proteins and regulators of these …

Ischemia, lack of blood flow, and reperfusion, return of blood flow, are a common
phenomenon affecting millions of Americans each year. Roughly 30,000 Americans per year …

Chloroquine (CQ) has been used for decades as the primary chemotherapeutic drug for the
treatment of malaria. The emergence of drug resistance in Plasmodium falciparum has been …