Cancer in the broader sense refers to more than 277 different types of cancer disease.
Scientists have identified different stage of cancers, indicating that several gene mutations …

The combination of next-generation sequencing and advanced computational data analysis
approaches has revolutionized our understanding of the genomic underpinnings of cancer …

Purpose: Isocitrate dehydrogenase (IDH) mutations in glioma patients confer longer survival
and may guide treatment decision making. We aimed to predict the IDH status of gliomas …

As more clinically relevant cancer genes are identified, comprehensive diagnostic
approaches are needed to match patients to therapies, raising the challenge of optimization …

The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway
is activated by upstream genomic events and/or activation of multiple signaling events in …

The systematic translation of cancer genomic data into knowledge of tumour biology and
therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust …

Despite recent insights into melanoma genetics, systematic surveys for driver mutations are
challenged by an abundance of passenger mutations caused by carcinogenic UV light …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Background Myelodysplastic syndromes are clinically heterogeneous disorders
characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood …