The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Atherosclerosis and cancer are chronic diseases considered two of the main causes of
death all over the world. Taking into account that both diseases are multifactorial, they share …

Background Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B
member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation …

Chemotherapy is one of the important methods to treat cancer, and the emergence of
multidrug resistance (MDR) is one major cause for the failure of cancer chemotherapy …

Lung cancer is one of the most common cancer types worldwide and causes more than one
million deaths annually. Lung adenocarcinoma (AC) and lung squamous cell cancer (SCC) …

Antiapoptotic Bcl-2-family members are well known for their 'mitochondrial'functions as
critical neutralizers of proapoptotic Bcl-2-family members, including the executioner …

Nutrient supply and demand delineate cell behavior in health and disease. Mammalian cells
have developed multiple strategies to secure the necessary nutrients that fuel their …

Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation
(OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2 …

Highlights•Drug resistance of cancer cells, which results in treatment failure, is a major
concern in medical oncology.•Ca 2+ plays an important role in acquired drug resistance by …

Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics driven by a
combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons …