Clinical applications of EEG power spectra aperiodic component analysis: A mini-review
Objective The present mini-review summarizes recent clinical findings related to the analysis
of the aperiodic component of EEG (electroencephalographic) power spectra, making them …
of the aperiodic component of EEG (electroencephalographic) power spectra, making them …
Bringing machine learning to research on intellectual and developmental disabilities: taking inspiration from neurological diseases
Abstract Intellectual and Developmental Disabilities (IDDs), such as Down syndrome,
Fragile X syndrome, Rett syndrome, and autism spectrum disorder, usually manifest at birth …
Fragile X syndrome, Rett syndrome, and autism spectrum disorder, usually manifest at birth …
Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial
EM Berry-Kravis, MD Harnett, SA Reines, MA Reese… - Nature medicine, 2021 - nature.com
The goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric
inhibitor (BPN14770) would improve cognitive function and behavioral outcomes in patients …
inhibitor (BPN14770) would improve cognitive function and behavioral outcomes in patients …
Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability
CL Wilkinson, CA Nelson - Molecular autism, 2021 - Springer
Background The lack of robust and reliable clinical biomarkers in Fragile X Syndrome (FXS),
the most common inherited form of intellectual disability, has limited the successful …
the most common inherited form of intellectual disability, has limited the successful …
Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1−/y mouse model of autism
AA Bhaskaran, T Gauvrit, Y Vyas, G Bony… - Nature …, 2023 - nature.com
Excessive neural variability of sensory responses is a hallmark of atypical sensory
processing in autistic individuals with cascading effects on other core autism symptoms but …
processing in autistic individuals with cascading effects on other core autism symptoms but …
Neocortical localization and thalamocortical modulation of neuronal hyperexcitability contribute to Fragile X Syndrome
Abstract Fragile X Syndrome (FXS) is a monogenetic form of intellectual disability and
autism in which well-established knockout (KO) animal models point to neuronal …
autism in which well-established knockout (KO) animal models point to neuronal …
Sex differences in neuronal systems function and behaviour: beyond a single diagnosis in autism spectrum disorders
OOF Williams, M Coppolino, ML Perreault - Translational Psychiatry, 2021 - nature.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is
associated with functional brain alterations that underlie the expression of behaviour. Males …
associated with functional brain alterations that underlie the expression of behaviour. Males …
Developmental delays in cortical auditory temporal processing in a mouse model of Fragile X syndrome
K Croom, JA Rumschlag, MA Erickson… - Journal of …, 2023 - Springer
Background Autism spectrum disorders (ASD) encompass a wide array of debilitating
symptoms, including sensory dysfunction and delayed language development. Auditory …
symptoms, including sensory dysfunction and delayed language development. Auditory …
Acute pharmacological inhibition of matrix metalloproteinase‐9 activity during development restores perineuronal net formation and normalizes auditory processing in …
Abstract Individuals with Fragile X Syndrome (FXS) and autism spectrum disorder (ASD)
exhibit cognitive impairments, social deficits, increased anxiety, and sensory …
exhibit cognitive impairments, social deficits, increased anxiety, and sensory …
EEG as a translational biomarker and outcome measure in fragile X syndrome
A Kenny, D Wright, AC Stanfield - Translational Psychiatry, 2022 - nature.com
Targeted treatments for fragile X syndrome (FXS) have frequently failed to show efficacy in
clinical testing, despite success at the preclinical stages. This has highlighted the need for …
clinical testing, despite success at the preclinical stages. This has highlighted the need for …