Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is a risk
factor for dementia later in life. Research into the pathophysiology of TBI has focused on the …

Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …

Sleep quality declines with age; however, the underlying mechanisms remain elusive. We
found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation …

Fragile X syndrome (FXS), an inherited intellectual disability often associated with autism, is
caused by the loss of expression of the fragile X mental retardation protein. Tremendous …

Over 130 brain diseases are caused by mutations that disrupt genes encoding the proteome
of excitatory synapses. These include neurological and psychiatric disorders with early and …

Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The
cause for this X-linked disorder is the silencing of the fragile X mental retardation 1 (fmr1) …

Dendrite morphology is pivotal for neural circuitry functioning. While the causative
relationship between small-scale dendrite morphological abnormalities (shape, density of …

Cellular and circuit hyperexcitability are core features of fragile X syndrome and related
autism spectrum disorder models. However, the cellular and synaptic bases of this …

Introduction The neurodevelopmental disorder fragile X syndrome (FXS) is the most
common monogenic cause of intellectual disability associated with autism spectrum …

Fragile X syndrome (FXS), a commonly inherited form of autism and intellectual disability, is
associated with emotional symptoms that implicate dysfunction of the amygdala. However …