While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …

Cells and soluble mediators of the innate and adaptive immune systems are fundamental
components of the tumor microenvironment. Nuclear factors, eg transcription factors (TFs) …

Introduction: Prostate cancer (PCa), one of the most prevalent malignancies affecting men
worldwide, presents significant challenges in terms of early detection, risk stratification, and …

NKX3. 1 is the most commonly deleted gene in prostate cancer and a gatekeeper
suppressor. NKX3. 1 is a growth suppressor, mediator of apoptosis, inducer of antioxidants …

The high-altitude environment is characterized by hypobaric hypoxia, low temperatures, low
humidity, and high radiation, which is a natural challenge for lowland residents entering …

The well-known androgen-regulated homeobox gene, NKX3. 1, is located on the short arm
of chromosome 8. It is the first known prostate epithelium-specific marker, and is a …

Prostate cancer is one of the main causes of male cancer-related deaths worldwide and the
suppression of androgen receptor signalling is established as an effective strategy for the …

The androgen receptor (AR) is expressed in 60%–70% of breast cancers regardless of
estrogen receptor status, and has been proposed as a therapeutic target in breast cancers …

Proteostasis regulates key cellular processes such as cell proliferation, differentiation,
transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial …

The androgen receptor (AR) is a steroid hormone receptor and its high expression and
disruption of its regulation are strongly implicated in prostate cancer (PCa) development …