Summary We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until
December 2014 and included 133 randomised controlled trials of peri‐operative gabapentin …

Background: Gabapentin and pregabalin inhibit Ca2+ currents via high-voltage-activated
channels containing the α2δ-1 subunit, reducing neurotransmitter release and attenuating …

Background Perioperative pain treatment often consist of combinations of non‐opioid and
opioid analgesics,'multimodal analgesia', in which gabapentin is currently used. The aim …

Background Pregabalin (PGB) and gabapentin (GBP) are current and emerging drugs in the
field of pre-emptive preoperative analgesia. However, the role of PGB or GBP in acute …

BACKGROUND: Preoperative gabapentin has been shown to improve postoperative pain
and limit reliance on opioid analgesia. On the basis of an alternative mechanism, our group …

Background: Gabapentin (GBP), originally an antiepileptic drug, is more commonly used in
the treatment of neuropathic pain. In recent years, GBP has been used as an adjunct or …

Introduction Postoperative nausea and vomiting (PONV) is frequently encountered in the
surgical recovery room. Abdominal surgery is one important risk factor for increased …

Background Hyperemesis gravidarum is a disabling disease of nausea, vomiting, and
undernutrition in early pregnancy for which there are no effective outpatient therapies. Poor …

Gabapentin's main clinical use is in the treatment of neuropathic pain where its binding to
neuronal alpha-2/delta subunits of voltage-gated calcium channels (VGCCs) is critical to its …

Background During the last 15 years, gabapentin has become an established component of
postoperative pain treatment. Gabapentin has been employed in a wide range of doses, but …