Glucose-induced insulin secretion in response to a step increase in blood glucose
concentrations follows a biphasic time course consisting of a rapid and transient first phase …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by
intrapancreatic nerve endings during the preabsorptive and absorptive phases of feeding. In …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

It is becoming increasingly apparent that beta cell dysfunction resulting in abnormal insulin
secretion is the essential element in the progression of patients from a state of impaired …

A readily releasable pool (RRP) of granules has been proposed to underlie the first phase of
insulin secretion. In the present study we combined electron microscopy, insulin secretion …

NeuroD, a transactivator of the insulin gene, is critical for development of the endocrine
pancreas, and NeuroD mutations cause MODY6 in humans. To investigate the role of …

Secretion of the peptide hormone insulin from pancreatic β cells constitutes an important
step in the regulation of body homeostasis. Insulin is stored in large dense core vesicles and …

In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying
mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We …

Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca 2+
resulting from enhanced Ca 2+ influx through voltage‐gated Ca 2+ channels. Mouse β cells …