Sepsis is a severe medical condition characterized by a systemic inflammatory response,
often culminating in multiple organ dysfunction and high mortality rates. In recent years …

The orphan G-protein-coupled receptor 35 (GPR35), although poorly characterised, is
attracting considerable interest as a therapeutic target. Marked differences in pharmacology …

Precise killing of tumor cells without affecting surrounding normal cells is a challenge.
Mitochondrial DNA (mtDNA) mutations, a common genetic variant in cancer, can directly …

The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been
recently linked to a number of inflammatory diseases. Here, we report that the release of mt …

PANoptosis is a new type of cell death featured with pyroptosis, apoptosis and necroptosis,
and is implicated in organ injury and mortality in various inflammatory diseases, such as …

Dengue virus (DENV) infection remains a challenging health threat worldwide. Ubiquitin-
specific protease 18 (USP18), which preserves the anti-interferon (IFN) effect, is an ideal …

Elesclomol (ES), a copper-binding ionophore, forms an ES–Cu complex with copper ions
(Cu (II)). ES–Cu has been proven to induce mitochondrial oxidative stress and copper …

Mitochondria have multiple functions such as supplying energy, regulating the redox status,
and producing proteins encoded by an independent genome. They are closely related to the …

In the context of stroke and revascularization therapy, brain ischemia-reperfusion injury is a
significant challenge that leads to oxidative stress and inflammation. Central to the cell's …

Infection of Rift Valley fever virus (RVFV), a highly pathogenic mosquito-borne zoonotic
virus, triggers severe inflammatory pathogenesis but the underlying mechanism of …