Lysine crotonylation has been discovered in histone and non-histone proteins and found to
be involved in diverse diseases and biological processes, such as neuropsychiatric disease …

Interpretation of the histone posttranslational modifications (PTMs) by effector proteins, or
readers, is an important epigenetic mechanism to regulate gene function. YEATS domains …

Bromodomains (BRDs) are conserved protein interaction modules which recognize (read)
acetyl-lysine modifications, however their role (s) in regulating cellular states and their …

Fragment-based drug discovery (FBDD) has grown and matured to a point where it is
valuable to keep track of its extent and details of application. This Perspective summarizes …

Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling,
represent tractable targets to modulate tumorigenic gene expression programs with small …

This Perspective, the fourth in an annual series, summarizes fragment-to-lead (F2L) success
stories published during 2018. Topics such as target class, screening methods …

A series of small-molecule YEATS4 binders have been discovered as part of an ongoing
research effort to generate high-quality probe molecules for emerging and/or challenging …

Epigenetic reader proteins interpret histone epigenetic marks to regulate gene expression.
Given their vital roles and the link between their dysfunction and various diseases, these …

Eleven-nineteen leukemia (ENL) protein is a histone acetylation reader essential for disease
maintenance in acute leukemias, in particular, the mixed-lineage leukemia (MLL) …

Lysine crotonylation (Kcr) is a histone post-translational modification that is implicated in
numerous epigenetic pathways and diseases. Recognition of Kcr by YEATS domains has …