Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares
the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other …

Recent evidence suggests the global incidence and mortality of hepatocellular carcinoma
(HCC) are increasing. Although the highest incidence of HCC remains entrenched in WHO …

2D culture as a model for drug testing often turns to be clinically futile. Therefore, 3D cultures
(3Ds) show potential to better model responses to drugs observed in vivo. In preliminary …

Background In ovarian cancer (OC) therapy, even initially responsive patients develop drug
resistance. Methods Here, we present an OC cell model composed of variants with differing …

Debulking surgery followed by chemotherapy are the standard of care for high-grade serous
carcinoma. After an initial good response to treatment, the majority of patients relapse with a …

Polo-like kinases (PLKs) belong to a five-membered family of highly conserved
serine/threonine kinases (PLK1-5) that play differentiated and essential roles as key mitotic …

Taxanes are natural compounds with strong antitumor activity. In this study, we first extracted
taxanes from the needles of Taxus cuspidata using ultrasonic (US) extraction, and then …

Epithelial ovarian cancer (EOC) is a fatal gynecological malignant tumor with a low 5‑year
survival rate. The use of the first‑line chemotherapeutic drug, paclitaxel, for the treatment of …

Background: Anlotinib is a highly potent multi-target tyrosine kinase inhibitor. Accumulating
evidence suggests that anlotinib exhibits effective anti-tumor activity against various cancer …

Transcriptome studies which provide temporal information can be valuable for identifying
groups of similarly-behaving transcripts and provide insight into overarching gene regulatory …