Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

The cell microenvironment, which is critical for stem cell maintenance, contains both cellular
and non-cellular components, including secreted growth factors and the extracellular matrix …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

Calcitonin gene-related peptide (CGRP) is a highly potent vasoactive peptide released from
sensory nerves, which is now proposed to have protective effects in several cardiovascular …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

Migraine is a common episodic neurovascular brain disorder associated with increased risk
of cardio-and cerebrovascular ischemia. Migraine headache is likely caused by activation of …