Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Accumulating evidence indicates that obesity is closely associated with an increased risk of
metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Emerging data suggest that obesity is a major risk factor for the progression of major
complications such as acute respiratory distress syndrome (ARDS), cytokine storm and …

Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ.
Besides adipocytes, adipose tissue contains connective tissue matrix, nerve tissue …

The relationship between obesity and hypertension is well established both in children and
adults. The mechanisms through which obesity directly causes hypertension are still an area …

Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …

The classical perception of adipose tissue as a storage place of fatty acids has been
replaced over the last years by the notion that adipose tissue has a central role in lipid and …