Ionizing radiation and complex DNA damage: quantifying the radiobiological damage using Monte Carlo simulations

KP Chatzipapas, P Papadimitroulas, D Emfietzoglou… - Cancers, 2020 - mdpi.com
Ionizing radiation is a common tool in medical procedures. Monte Carlo (MC) techniques are
widely used when dosimetry is the matter of investigation. The scientific community has …

[HTML][HTML] Toward A variable RBE for proton beam therapy

H Willers, A Allen, D Grosshans, SJ McMahon… - Radiotherapy and …, 2018 - Elsevier
In the clinic, proton beam therapy (PBT) is based on the use of a generic relative biological
effectiveness (RBE) of 1.1 compared to photons in human cancers and normal tissues …

The linear quadratic model: usage, interpretation and challenges

SJ McMahon - Physics in Medicine & Biology, 2018 - iopscience.iop.org
The linear-quadratic model is one of the key tools in radiation biology and physics. It
provides a simple relationship between cell survival and delivered dose:, and has been …

Geant4‐DNA example applications for track structure simulations in liquid water: a report from the Geant4‐DNA Project

S Incerti, I Kyriakou, MA Bernal, MC Bordage… - Medical …, 2018 - Wiley Online Library
This Special Report presents a description of Geant4‐DNA user applications dedicated to
the simulation of track structures (TS) in liquid water and associated physical quantities (eg …

TOPAS-nBio: an extension to the TOPAS simulation toolkit for cellular and sub-cellular radiobiology

J Schuemann, AL McNamara… - Radiation …, 2019 - meridian.allenpress.com
The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging
research, having played a significant role in making Monte Carlo simulations widely …

Mechanistic DNA damage simulations in Geant4-DNA part 1: A parameter study in a simplified geometry

N Lampe, M Karamitros, V Breton, JMC Brown… - Physica Medica, 2018 - Elsevier
Mechanistic modelling of DNA damage in Monte Carlo simulations is highly sensitive to the
parameters that define DNA damage. In this work, we use a simple testing geometry to …

Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

D Sakata, N Lampe, M Karamitros, I Kyriakou, O Belov… - Physica Medica, 2019 - Elsevier
The advancement of multidisciplinary research fields dealing with ionising radiation induced
biological damage–radiobiology, radiation physics, radiation protection and, in particular …

Mechanistic modelling of radiation responses

SJ McMahon, KM Prise - Cancers, 2019 - mdpi.com
Radiobiological modelling has been a key part of radiation biology and therapy for many
decades, and many aspects of clinical practice are guided by tools such as the linear …

Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio

J Ramos-Méndez, J Perl, J Schuemann… - Physics in Medicine …, 2018 - iopscience.iop.org
Simulation of water radiolysis and the subsequent chemistry provides important information
on the effect of ionizing radiation on biological material. The Geant4 Monte Carlo toolkit has …

Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo …

WB Li, A Belchior, M Beuve, YZ Chen, S Di Maria… - Physica Medica, 2020 - Elsevier
Purpose Targeted radiation therapy has seen an increased interest in the past decade. In
vitro and in vivo experiments showed enhanced radiation doses due to gold nanoparticles …