It is emerging that the pathways that process newly transcribed RNA molecules also
regulate the response to DNA damage at multiple levels. Here, we discuss recent insights …

The cancer immunoediting hypothesis assumes that the immune system guards the host
against the incipient cancer, but also “edits” the immunogenicity of surviving neoplastic cells …

Exposure to ionizing radiation (IR) is inevitable to humans in real-life scenarios; the hazards
of IR primarily stem from its mutagenic, carcinogenic, and cell killing ability. For many …

Purpose MicroRNAs (miRNAs) were hypothesized to be robust and easily measured
biomarkers of radiation exposure, which has led to multiple studies in various clinical and …

Background High dose ionizing radiation (IR) induces potent toxic cell effects mediated by
either direct DNA damage or the production of reactive oxygen species (ROS). IR-induced …

Robust predictive models are essential to manage the risk of radiation-induced
carcinogenesis. Chronic exposure to cosmic rays in the context of the complex deep space …

Individual variation in radiosensitivity is thought to be at least partly determined by genetic
factors. The remaining difference between individuals is caused by comorbidities, variation …

In accordance with the 3 Rs principle (to replace, reduce and refine) animal models in
biomedical research, we have developed and applied a new approach for sampling and …

Radio-adaptive response is a mechanism whereby a low-dose exposure (priming dose)
induces resistance to a higher dose (challenging dose) thus significantly reducing its …

The results of clinical trials performed from the 1930s until the end of the 20th century in
which total-body ultra-low level ionizing radiation (TB-LLR) was used demonstrate that this …