Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …

DNA methylation is a well-studied epigenetic modification that has key roles in regulating
gene expression, maintaining genome integrity, and determining cell fate. Precisely how …

Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct
cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics …

Chromatin modifications and the promoter-associated epigenome are important for the
regulation of gene expression. However, the mechanisms by which chromatin-modifying …

The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays
important roles in epigenetic regulation by targeting various activities to CpG islands. Here …

Understanding the underlying molecular mechanisms of defined cancers is crucial for
effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene …

Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …

Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged
leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global …

Accumulating recent evidence supports the notion that many enzymes that modify histones
are fundamental players in normal hematopoiesis as well as hematologic malignancies, and …